Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.41 |
| ▸ | NQO1 | P15559 | 1/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 11/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1547677 | 0.84 | MAPT (0.54) | MAPTNQO1 | |
| SCHEMBL3780893 | 0.84 | NQO1 (0.50) | MAPTNQO1 | |
| SCHEMBL1680217 | 0.84 | NQO1 (0.50) | MAPTFGFR1FGFR2NQO1KAT6A | |
| SCHEMBL5671801 | 0.84 | NQO1 (0.50) | FGFR1FGFR2NQO1KAT6A | |
| SCHEMBL12093390 | 0.77 | ESR1 (0.50) | MAPTFGFR1FGFR2NQO1KAT6A | |
| SCHEMBL256791 | 0.77 | NQO1 (0.42) | MAPTFGFR1FGFR2NQO1KAT6A | |
| SCHEMBL16956758 | 0.77 | MAPT (0.42) | MAPTNQO1KAT6A | |
| SCHEMBL27870127 | 0.76 | MAPT (0.43) | MAPTEPAS1VEGFA | |
| SCHEMBL12497629 | 0.76 | MAPT (0.43) | MAPTEPAS1VEGFA | |
| SCHEMBL31405023 | 0.76 | ALDH1A1 (0.46) | EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11377434-B2 | Methods for preparing substituted chromanone derivatives | HANGZHOU DUYI TECHNOLOGY CO. LTD. (CN) | 2022-07-05 | — | — | US | disclosed |
| US-20220024890-A1 | METHODS FOR PREPARING SUBSTITUTED CHROMANONE DERIVATIVES | HANGZHOU DUYI TECHNOLOGY CO. LTD. (CN) | 2022-01-27 | — | — | US | disclosed |
| WO-2017117406-A1 | SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2017-07-06 | — | — | WO | disclosed |
| US-8183238-B2 | Bicyclic and tricyclic compounds as KAT II inhibitors | PFIZER INC. (US) | 2012-05-22 | — | — | US | disclosed |
| US-20100324043-A1 | Bicyclic And Tricyclic Compounds As KAT II Inhibitors | PFIZER INC | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324043-A1 | Bicyclic And Tricyclic Compounds As KAT II Inhibitors | KAT2A, KAT2B, KAT6B | MAPT 258/4885FGFR1 4561/4885FGFR2 4421/4885 |
| US-20220024890-A1 | METHODS FOR PREPARING SUBSTITUTED CHROMANONE DERIVATIVES | CBR3, CYP2F1, CBR1 | MAPT 4832/4885FGFR1 3592/4885FGFR2 4001/4885 |
| US-11377434-B2 | Methods for preparing substituted chromanone derivatives | CYP2E1, CYP2F1, CBR1 | MAPT 4832/4885FGFR1 3465/4885FGFR2 4125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.