SCHEMBL6832831

SCHEMBL6832831

C[C@@H](N1CCN(c2ccc(OCC(F)(F)C(F)F)cc2)C1=O)[C@](O)(Cn1cncn1)c1ccccc1F

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 12/20 0.39
CYP2C9 P11712 11/20 0.39
CYP2C19 P33261 11/20 0.39
CYP1A2 P05177 6/20 0.39
CYP2D6 P10635 6/20 0.39
KCNH2 Q12809 3/20 0.39
LMNA P02545 2/20 0.37
CYP2B6 P20813 1/20 0.37
CYP3A5 P20815 1/20 0.37
CYP3A7 P24462 1/20 0.37
MAPK1 P28482 1/20 0.37
CYP3A43 Q9HB55 1/20 0.37
CYP46A1 Q9Y6A2 1/20 0.37
ACACB O00763 1/20 0.34
ABCG2 Q9UNQ0 1/20 0.32
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8106760 0.91 CYP3A4 (0.49) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8112842 0.91 CYP3A4 (0.39) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8541880 0.88 KMT2A (0.37) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8105653 0.86 ACACB (0.36) ACACBLIPEHTTKMT2A
SCHEMBL8105650 0.86 ACACB (0.36) ACACBLIPEHTTKMT2A
SCHEMBL8540080 0.86 SCN9A (0.36) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8540205 0.85 CYP3A4 (0.48) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL7680530 0.85 CYP3A4 (0.41) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL7684921 0.84 CYP3A4 (0.41) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8669563 0.84 CYP3A4 (0.40) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5814324-A OIL IN WATER EMULSION COMPRISING ANTIFUNGAL TRIAZOLE COMPOUND DISPERSED IN WATER WITH FATTY ACID TRIGLYCERIDE, LECITHIN EMULSIFIER TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-29 US claimed
EP-0657449-B1 Azole compounds, their production and use as antifungal agents TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-04-08 EP claimed
US-5545652-A Triazole and imidazole compounds and their use as antifungal therapeutic agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-08-13 US claimed
US-6743432-B1 MEMBRANE HAVING LOW ADSORPTIVITY FOR PROTEIN; HOMO- OR CO-POLYMER OF FLUORINE-CONTAINING MONOMER INCLUDING HYDROPHILIC GROUP, HYDROPHILIZED POLYSULFONE INCORPORATING WETTING AGENT, HYDROPHILIZED CELLULOSE DERIVATIVE HISAMITSU PHARMACEUTICAL CO., INC. (JP) 2004-06-01 US disclosed
EP-0747092-B1 Matrix for iontophoresis HISAMITSU PHARMACEUTICAL CO (JP) 2003-12-03 EP disclosed
EP-0748636-B1 Interface for iontophoresis HISAMITSU PHARMACEUTICAL CO (JP) 2003-08-27 EP disclosed
US-6248349-B1 LIQUID HUMECTANT HISAMITSU PHARMACEUTICAL CO., INC. (JP) 2001-06-19 US disclosed
EP-1033367-A2 Process for the preparation of optically active triazole derivatives and their imidazolidin-2-one intermediates TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 2000-09-06 EP disclosed
US-5993848-A Dissolution liquid for drug in iontophoresis TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1999-11-30 US disclosed
EP-0884311-A2 Triazole Derivatives and their production Takeda Chemical Industries, Ltd. (JP) 1998-12-16 EP disclosed
US-5814324-A OIL IN WATER EMULSION COMPRISING ANTIFUNGAL TRIAZOLE COMPOUND DISPERSED IN WATER WITH FATTY ACID TRIGLYCERIDE, LECITHIN EMULSIFIER TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-29 US disclosed
US-5792780-A FUNGICIDES TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-08-11 US disclosed
EP-0657449-B1 Azole compounds, their production and use as antifungal agents TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1998-04-08 EP disclosed
US-5677464-A Production of optically active triazole compounds and their intermediates TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-14 US disclosed
EP-0748636-A2 Interface for iontophoresis TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-12-18 EP disclosed
EP-0747092-A2 Dissolution liquid for drug in iontophoresis TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-12-11 EP disclosed
US-5545652-A Triazole and imidazole compounds and their use as antifungal therapeutic agents TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-08-13 US disclosed
EP-0687672-A2 Production of optically active triazole compounds and their intermediates TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-12-20 EP disclosed
EP-0657449-A1 Azole compounds, their production and use as antifungal agents Takeda Chemical Industries, Ltd. (JP) 1995-06-14 EP disclosed