SCHEMBL8669563

SCHEMBL8669563

C[C@@H](n1ncn(-c2ccc(OCC(F)(F)C(F)F)cc2)c1=O)[C@](O)(Cn1cncn1)c1ccccc1F

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 18/20 0.40
CYP2C9 P11712 9/20 0.40
CYP2C19 P33261 8/20 0.40
CYP1A2 P05177 5/20 0.39
CYP2D6 P10635 5/20 0.39
KCNH2 Q12809 1/20 0.39
MAPK1 P28482 2/20 0.37
LMNA P02545 2/20 0.37
CYP2B6 P20813 1/20 0.37
CYP3A5 P20815 1/20 0.37
CYP3A7 P24462 1/20 0.37
CYP3A43 Q9HB55 1/20 0.37
CYP46A1 Q9Y6A2 1/20 0.37
ABCG2 Q9UNQ0 3/20 0.36
ABCB11 O95342 2/20 0.36
CYP8B1 Q9UNU6 2/20 0.36
CYP17A1 P05093 1/20 0.36
CYP19A1 P11511 1/20 0.36
CYP11B1 P15538 1/20 0.36
CYP11B2 P19099 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9230891 0.93 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL19970516 0.91 CYP3A4 (0.51) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL19970517 0.91 CYP3A4 (0.51) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL1456168 0.91 CYP3A4 (0.51) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8671819 0.91 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8111206 0.89 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL8097537 0.89 CYP3A4 (0.42) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL9230972 0.89 CYP3A4 (0.43) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL7678338 0.88 CYP3A4 (0.49) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL7681431 0.88 CYP3A4 (0.48) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659751-A1 Optically active azole derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-06-28 EP claimed
US-5814324-A OIL IN WATER EMULSION COMPRISING ANTIFUNGAL TRIAZOLE COMPOUND DISPERSED IN WATER WITH FATTY ACID TRIGLYCERIDE, LECITHIN EMULSIFIER TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1998-09-29 US disclosed
EP-0659751-A1 Optically active azole derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-06-28 EP disclosed