Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6457954 | 1.00 | MAPT (0.38) | MAPTTP53ADRA2AMCHR1ALDH1A1 | |
| SCHEMBL6460993 | 0.90 | SMN1; SMN2 (0.40) | MAPTTP53ADRA2AMCHR1ALDH1A1 | |
| SCHEMBL6460982 | 0.90 | SMN1; SMN2 (0.40) | MAPTTP53ADRA2AMCHR1ALDH1A1 | |
| SCHEMBL6456641 | 0.89 | TP53 (0.41) | MAPTTP53ADRA2AMCHR1ALDH1A1 | |
| SCHEMBL6456647 | 0.89 | TP53 (0.41) | MAPTTP53ADRA2AMCHR1ALDH1A1 | |
| SCHEMBL6872800 | 0.89 | MCHR1 (0.46) | MAPTADRA2AMCHR1POLBRAB9A | |
| SCHEMBL6872807 | 0.89 | MCHR1 (0.46) | MAPTADRA2AMCHR1POLBRAB9A | |
| SCHEMBL6875342 | 0.86 | GAA (0.42) | MAPTADRA2AMCHR1ALDH1A1POLB | |
| SCHEMBL6875336 | 0.86 | GAA (0.42) | MAPTADRA2AMCHR1ALDH1A1POLB | |
| SCHEMBL6868226 | 0.85 | BCHE (0.46) | MAPTTP53ADRA2AMCHR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087669-A1 | NOVEL QUINOLINE, TETRAHYDROQUINAZOLINE, AND PYRIMIDINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF | TAISHO PHARMACEUTICAL CO. LTD. (JP) | 2004-10-14 | — | — | WO | claimed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | claimed |
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |