Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 3/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6872800 | 1.00 | MCHR1 (0.46) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6868701 | 0.91 | LMNA (0.45) | MCHR1ADRA2APOLBKMT2ARAB9A | |
| SCHEMBL6868693 | 0.91 | LMNA (0.45) | MCHR1ADRA2APOLBKMT2ARAB9A | |
| SCHEMBL6868226 | 0.91 | BCHE (0.46) | MCHR1ADRA2AKMT2ABCHEACHE | |
| SCHEMBL6868231 | 0.91 | BCHE (0.46) | MCHR1ADRA2AKMT2ABCHEACHE | |
| SCHEMBL6457954 | 0.89 | MAPT (0.38) | MCHR1ADRA2APOLBRAB9ANPC1 | |
| SCHEMBL6833719 | 0.89 | MAPT (0.38) | MCHR1ADRA2APOLBRAB9ANPC1 | |
| SCHEMBL6876710 | 0.89 | MCHR1 (0.50) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6876707 | 0.89 | MCHR1 (0.50) | MCHR1ADRA2ACNR1KCNH2AURKB | |
| SCHEMBL6875336 | 0.87 | GAA (0.42) | MCHR1ADRA2APOLBKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1464335-A2 | Quinoline, tetrahydroquinoline and pyrimidine derivatives as mch antagonist | Taisho Pharmaceutical Co. Ltd. (JP) | 2004-10-06 | — | — | EP | disclosed |