SCHEMBL683387

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL878268	1.00	PDE4B (0.45)	PDE4BFFAR4TRPC6HCRTR1HCRTR2
	SCHEMBL2140386	0.91	PDE4B (0.48)	PDE4BFFAR4PDE4APDE4CPDE4D
	SCHEMBL682038	0.91	PDE4B (0.48)	PDE4BFFAR4PDE4APDE4CPDE4D
	SCHEMBL682651	0.89	PDE4B (0.50)	PDE4BPDE4APDE4CPDE4D
	SCHEMBL2141419	0.89	PDE4B (0.50)	PDE4BPDE4APDE4CPDE4D
	SCHEMBL682652	0.87	NR1H2 (0.47)	PDE4BTRPC6PDE4A
	SCHEMBL876732	0.87	NR1H2 (0.47)	PDE4BTRPC6PDE4A
	SCHEMBL681978	0.87	HCRTR1 (0.40)	PDE4BFFAR4TRPC6HCRTR1HCRTR2
	SCHEMBL878088	0.87	HCRTR1 (0.40)	PDE4BFFAR4TRPC6HCRTR1HCRTR2
	SCHEMBL876549	0.85	HCRTR1 (0.39)	PDE4BFFAR4TRPC6HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.