Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 19/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 11/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | PLD2 | O14939 | 1/20 | 0.51 |
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | C5 | P01031 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6765919 | 0.90 | ESR1 (0.56) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6836607 | 0.89 | ESR1 (0.49) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL6767212 | 0.89 | ESR1 (0.55) | ESR1ESR2MEN1ALDH1A1LMNA | |
| 1,2-Dichloroethane SCHEMBL6766357 | 0.87 | ESR1 (0.53) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6835772 | 0.85 | ESR1 (0.53) | ESR1ESR2MEN1ALDH1A1LMNA | |
| Chlorobenzene SCHEMBL6765632 | 0.83 | ESR1 (0.49) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6832617 | 0.81 | ESR1 (0.61) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6836596 | 0.80 | ESR1 (0.49) | ESR1ESR2ALDH1A1HSD17B10CYP2D6 | |
| SCHEMBL5309771 | 0.80 | ESR1 (0.67) | ESR1ESR2MEN1ALDH1A1LMNA | |
| SCHEMBL6773072 | 0.79 | ESR1 (0.52) | ESR1ESR2TDP1CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756388-B1 | HAVING PIPERIDINYL AND PHENOLIC FUNCTIONALITY; BONE LOSS; BREAST OR PROSTATE CANCER | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |
| EP-0723537-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010513-A1 | BENZOTHIOPHENES AND RELATED COMPOUNDS AS ESTROGEN AGONISTS | PFIZER INC. (US) | 1995-04-20 | — | — | WO | disclosed |