Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 2/20 | 0.42 |
| ▸ | PDCD4 | Q53EL6 | 1/20 | 0.42 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.40 |
| ▸ | TUBB | P07437 | 1/20 | 0.40 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.40 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.40 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.40 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.40 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.40 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.40 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.40 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.40 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369251 | 0.90 | UCHL1 (0.53) | UCHL1ALDH1A1SMN1; SMN2TUBB4ATUBB | |
| SCHEMBL15182512 | 0.87 | UCHL1 (0.52) | UCHL1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL19730348 | 0.83 | UCHL1 (0.46) | UCHL1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL369288 | 0.81 | UCHL1 (0.49) | UCHL1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL15595830 | 0.81 | UCHL1 (0.51) | UCHL1ALDH1A1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL3583470 | 0.79 | SMN1; SMN2 (0.51) | UCHL1ALDH1A1LMNATARBP2PDCD4 | |
| SCHEMBL370013 | 0.79 | MAPT (0.46) | UCHL1ALDH1A1LMNATARBP2PDCD4 | |
| SCHEMBL18387731 | 0.78 | UCHL1 (1.00) | UCHL1ALDH1A1LMNAMAPTTUBB4A | |
| SCHEMBL23294430 | 0.77 | UCHL1 (0.56) | UCHL1ALDH1A1TARBP2PDCD4GABRA2 | |
| SCHEMBL19730351 | 0.77 | UCHL1 (0.49) | UCHL1ALDH1A1LMNAMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111018861-B | Pyrrolopyrimidine compounds | 正大天晴药业集团股份有限公司 | 2021-11-19 | — | — | CN | disclosed |
| EP-3235819-B1 | PYRROLOPYRIMIDINE COMPOUNDS USEFUL AS JAK INHIBITORS | CENTAURUS BIOPHARMA CO LTD (CN) | 2020-11-18 | — | — | EP | disclosed |
| CN-111018861-A | Pyrrolopyrimidine compounds | 正大天晴药业集团股份有限公司 | 2020-04-17 | — | — | CN | disclosed |
| US-10561657-B2 | Pyrrolopyrimidine compound | Centaurus Biophrama Co., Ltd. (CN) | 2020-02-18 | — | — | US | disclosed |
| US-20190201403-A1 | PYRROLOPYRIMIDINE COMPOUND | LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD. (CN) | 2019-07-04 | — | — | US | disclosed |
| EP-3235819-A1 | PYRROLOPYRIMIDINE COMPOUND | Centaurus BioPharma Co., Ltd. (CN) | 2017-10-25 | — | — | EP | disclosed |
| US-20130210807-A1 | Tricyclic Compounds as Allosteric Modulators of Metabotropic Glutamate Receptors. | MERCK SHARP & DOHME CORP. | 2013-08-15 | — | — | US | disclosed |
| WO-2012006760-A1 | TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012008999-A2 | TRICYCLIC COMPOUNDS AS ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK SHARP & DOHME CORP. (US) | 2012-01-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130210807-A1 | Tricyclic Compounds as Allosteric Modulators of Metabotropic Glutamate Receptors. | GRM3, GRM6, GRM1 | UCHL1 3480/4885ALDH1A1 3550/4885LMNA 4751/4885 |
| US-10561657-B2 | Pyrrolopyrimidine compound | JAK2, JAK1, JAK3 | UCHL1 4606/4885ALDH1A1 1027/4885LMNA 4875/4885 |
| US-20190201403-A1 | PYRROLOPYRIMIDINE COMPOUND | JAK2, JAK1, JAK3 | UCHL1 4606/4885ALDH1A1 1027/4885LMNA 4875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.