Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGK1 | P00558 | 3/20 | 0.57 |
| ▸ | PGK2 | P07205 | 3/20 | 0.57 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.51 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.51 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595603 | 1.00 | PGK1 (0.57) | PGK1PGK2ADORA2AADORA3ADORA2B | |
| SCHEMBL7596097 | 0.94 | ADORA2A (0.58) | PGK1PGK2ADORA2AADORA3ADORA2B | |
| SCHEMBL7594742 | 0.94 | ADORA2A (0.58) | PGK1PGK2ADORA2AADORA3ADORA2B | |
| SCHEMBL6839057 | 0.94 | ADORA2A (0.58) | PGK1PGK2ADORA2AADORA3ADORA2B | |
| SCHEMBL6839796 | 0.90 | ADORA2A (0.72) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6839042 | 0.90 | ADORA2A (0.72) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL6835061 | 0.89 | ADORA2A (0.53) | PGK1PGK2ADORA2AADORA3 | |
| SCHEMBL8087286 | 0.89 | ADORA2A (0.53) | PGK1PGK2ADORA2AADORA3 | |
| SCHEMBL7639455 | 0.89 | ADORA2A (0.53) | PGK1PGK2ADORA2AADORA3 | |
| SCHEMBL7598531 | 0.89 | ADORA2A (0.53) | PGK1PGK2ADORA2AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762170-B1 | ANTIINFLAMMATORY AGENTS INHIBIT LEUKOCYTE RECRUITMENT AND ACTIVATION AND ARE AGONISTS OF THE ADENOSINE 2A RECEPTOR; PENDANT ISOXAZOLE; REACTING A 2,6-DIAMINOPURINE WITH A 2-(3-SUBSTITUTED ISOXAZOL-5-YL)TETRAHYDROFURAN-3,4-DIOL | SMITHKLINEBEECHAM CORPORATION | 2004-07-13 | — | — | US | claimed |
| WO-2003080604-A1 | DIHYDROISOXAZOLYL SUBSTITUTED TETRAHYDROFURAN COOMPOUNDS AS INTERMEDIATES IN THE PREPARATION OF 2-(PURIN-9-YL) - TETRAHYDROFURAN DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | claimed |
| EP-1051425-B1 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-10-30 | — | — | EP | claimed |
| EP-1051425-A2 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-11-15 | — | — | EP | claimed |
| WO-1999038877-A2 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-08-05 | — | — | WO | claimed |
| US-6762170-B1 | ANTIINFLAMMATORY AGENTS INHIBIT LEUKOCYTE RECRUITMENT AND ACTIVATION AND ARE AGONISTS OF THE ADENOSINE 2A RECEPTOR; PENDANT ISOXAZOLE; REACTING A 2,6-DIAMINOPURINE WITH A 2-(3-SUBSTITUTED ISOXAZOL-5-YL)TETRAHYDROFURAN-3,4-DIOL | SMITHKLINEBEECHAM CORPORATION | 2004-07-13 | — | — | US | disclosed |
| WO-2003080604-A1 | DIHYDROISOXAZOLYL SUBSTITUTED TETRAHYDROFURAN COOMPOUNDS AS INTERMEDIATES IN THE PREPARATION OF 2-(PURIN-9-YL) - TETRAHYDROFURAN DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-10-02 | — | — | WO | disclosed |
| EP-1051425-B1 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2002-10-30 | — | — | EP | disclosed |
| WO-2002036816-A2 | METHOD OF DETERMINING SUSCEPTIBILITY TO DISEASES | GLAXO GROUP LIMITED (GB) | 2002-05-10 | — | — | WO | disclosed |
| EP-1051425-A2 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999038877-A2 | 2-(PURIN-9-yl)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-08-05 | — | — | WO | disclosed |