Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL264745 | 1.00 | FOLH1 (0.50) | FOLH1CYP2C9CYP2D6CYP2C19SLC6A2 | |
| SCHEMBL11141533 | 1.00 | FOLH1 (0.50) | FOLH1CYP2C9CYP2D6CYP2C19SLC6A2 | |
| SCHEMBL17374631 | 0.85 | IRAK4 (0.47) | CYP2C9CYP2D6CYP2C19SLC6A2TAAR1 | |
| SCHEMBL1048951 | 0.85 | CYP2D6 (0.46) | CYP2C9CYP2D6CYP2C19SLC6A2TAAR1 | |
| SCHEMBL157592 | 0.85 | FOLH1 (0.53) | FOLH1CYP2C9ALDH1A1ALOX15TSHR | |
| SCHEMBL8194054 | 0.85 | FOLH1 (0.53) | FOLH1CYP2C9CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL19285676 | 0.84 | GAA (0.49) | CYP2C9CYP2D6CYP2C19SLC6A2TAAR1 | |
| SCHEMBL17799517 | 0.83 | FOLH1 (0.52) | FOLH1CYP2C9ALDH1A1ALOX15TSHR | |
| SCHEMBL18301542 | 0.82 | FOLH1 (0.56) | FOLH1CYP2C9SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL28766027 | 0.82 | CYP2D6 (0.43) | CYP2C9CYP2D6CYP2C19SLC6A2TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4772586-A | ANTAGONISTS OF ANTIDIURETIC AND VASOPRESSOR ACTIVITY OF HORMONE | MEDICAL COLLEGE OF OHIO (US) | 1988-09-20 | — | — | US | claimed |
| EP-0273645-A2 | Novel derivatives of arginine vasopressin antagonists | THE MEDICAL COLLEGE OF OHIO (US) | 1988-07-06 | — | — | EP | claimed |
| US-4714696-A | Novel derivatives of arginine vasopressin antagonists | MEDICAL COLLEGE OF OHIO (US) | 1987-12-22 | — | — | US | claimed |
| US-4649130-A | Novel derivatives of arginine vasopressin antagonists | MEDICAL COLLEGE OF OHIO (US) | 1987-03-10 | — | — | US | claimed |
| EP-0189326-A2 | Derivatives of arginine vasopressin antagonists | Medical College of Ohio (US) | 1986-07-30 | — | — | EP | claimed |
| US-4551445-A | Derivatives of arginine vasopressin antagonists | THE MEDICAL COLLEGE OF OHIO (US) | 1985-11-05 | — | — | US | claimed |
| EP-0151016-A2 | Arginine vasopressin antagonists | Medical College of Ohio (US) | 1985-08-07 | — | — | EP | claimed |
| EP-0061356-B1 | ANTAGONISTS OF THE ANTIDIURETIC AND/OR VASOPRESSOR ACTION OF ARGININE VASOPRESSIN | Medical College of Ohio (US) | 1985-07-17 | — | — | EP | claimed |
| EP-0138604-A2 | Arginine vasopressin antagonists | Medical College of Ohio (US) | 1985-04-24 | — | — | EP | claimed |
| US-4399125-A | CYCLIC OLIGOPEPTIDES | TRUSTEES OF COLUMBIA UNIVERSITY THE, A CORP. OF NY. | 1983-08-16 | — | — | US | claimed |
| EP-0061356-A2 | Antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin | Medical College of Ohio (US) | 1982-09-29 | — | — | EP | claimed |
| CN-114853866-A | Peptidomimetic macrocycles | 艾瑞朗医疗公司 | 2022-08-05 | — | — | CN | disclosed |
| CN-112500466-B | Peptidomimetic macrocycles | 艾瑞朗医疗公司 | 2022-05-03 | — | — | CN | disclosed |
| CN-108348571-B | Peptidomimetic macrocycles and uses thereof | 艾瑞朗医疗公司 | 2022-03-22 | — | — | CN | disclosed |
| CN-114207129-A | Agents and methods for replication, transcription and translation in semi-synthetic organisms | 斯克利普斯研究所 | 2022-03-18 | — | — | CN | disclosed |
| EP-0138604-A2 | Arginine vasopressin antagonists | Medical College of Ohio (US) | 1985-04-24 | — | — | EP | disclosed |
| US-4491577-A | Antagonists of the antidiuretic action of arginine vasopressin | THE MEDICAL COLLEGE OF OHIO (US) | 1985-01-01 | — | — | US | disclosed |
| EP-0115379-A2 | Antagonists of the antidiuretic action of arginine vasopressin | Medical College of Ohio (US) | 1984-08-08 | — | — | EP | disclosed |
| US-4399125-A | CYCLIC OLIGOPEPTIDES | TRUSTEES OF COLUMBIA UNIVERSITY THE, A CORP. OF NY. | 1983-08-16 | — | — | US | disclosed |
| EP-0061356-A2 | Antagonists of the antidiuretic and/or vasopressor action of arginine vasopressin | Medical College of Ohio (US) | 1982-09-29 | — | — | EP | disclosed |