Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MMP9 | P14780 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839393 | 1.00 | CTNNB1 (0.38) | CTNNB1CTSSCTSKL3MBTL1CYP1A2 | |
| SCHEMBL967565 | 0.81 | CYP2A6 (0.40) | CTSSCTSKCYP2D6TACR1MMP9 | |
| SCHEMBL967564 | 0.81 | CYP2A6 (0.40) | CTSSCTSKCYP2D6TACR1MMP9 | |
| SCHEMBL4504374 | 0.80 | TAAR1 (0.33) | CYP1A2TDP1SIGMAR1ALDH1A1 | |
| SCHEMBL4504372 | 0.80 | TAAR1 (0.33) | CYP1A2TDP1SIGMAR1ALDH1A1 | |
| SCHEMBL6650896 | 0.80 | TAAR1 (0.33) | CYP1A2TDP1SIGMAR1ALDH1A1 | |
| SCHEMBL6650902 | 0.80 | TAAR1 (0.33) | CYP1A2TDP1SIGMAR1ALDH1A1 | |
| SCHEMBL970714 | 0.79 | HTR2A (0.41) | CTSSCTSKCYP1A2TACR1SIGMAR1 | |
| SCHEMBL660879 | 0.77 | AGXT (0.42) | — | |
| SCHEMBL6844414 | 0.77 | AGXT (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6767920-B2 | ADMINISTERING TO AN ANIMAL HAVING OCULAR HYPERTENSION OR GLAUCOMA THERAPEUTICALLY EFFECTIVE AMOUNT OF 3 OR 7 OR 3 AND 7 THIA-PROSTANOIC ACID, ESTER, AMIDE, PHOSPHONATE OR OTHER DERIVATIVES | ALLERGAN, INC. | 2004-07-27 | — | — | US | disclosed |
| US-20030144254-A1 | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure | ALLERGAN SALES, INC. | 2003-07-31 | — | — | US | disclosed |
| US-20030027853-A1 | Potent ocular hypotensives that are particularly suited for the management of glaucoma. | ALLERGAN SALES, INC. | 2003-02-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030027853-A1 | Potent ocular hypotensives that are particularly suited for the management of glaucoma. | CBR3, SCO2, CBR1 | CTNNB1 993/4885CTSS 2952/4885CTSK 4015/4885 |
| US-20030144254-A1 | 3, 7 or 3 and 7 thia or oxa prostanoic acid derivatives as agents for lowering intraocular pressure | PTGIR, OXER1, CBR1 | CTNNB1 764/4885CTSS 4532/4885CTSK 4802/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.