Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3A | Q14432 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | BLM | P54132 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | VCP | P55072 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | PNP | P00491 | 6/20 | 0.53 |
| ▸ | HPRT1 | P00492 | 10/20 | 0.51 |
| ▸ | HBB | P68871 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | EDNRA | P25101 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839494 | 1.00 | PDE3A (0.59) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL9651453 | 0.92 | BLM (0.65) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL9583727 | 0.89 | BLM (0.72) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL6377806 | 0.88 | BLM (0.72) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL6835357 | 0.88 | BLM (0.72) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL6840470 | 0.88 | BLM (0.72) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL10813642 | 0.88 | BLM (0.62) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| Hydrochloric Acid SCHEMBL6380553 | 0.88 | BLM (0.71) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL7919764 | 0.87 | BLM (0.59) | PDE3AMEN1KMT2ABLMALDH1A1 | |
| SCHEMBL8981399 | 0.87 | PNP (0.61) | PDE3AMEN1KMT2ABLMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040102462-A1 | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative | NESTOR JOHN J (US) | 2004-05-27 | — | — | US | disclosed |
| US-20020042424-A1 | 2- (2-amino-1, 6-dihydro-6 -oxo-purin-9 -yl) methoxy-1, 3 -propanediol derivative | ROCHE PALO ALTO LLC | 2002-04-11 | — | — | US | disclosed |
| US-6083953-A | Treating herpes simplex virus or cytomegalovirus infections; valganciclovir hydrochloride in crystalline form; antiviral; oral administration | SYNTEX (U.S.A.) INC. (US) | 2000-07-04 | — | — | US | disclosed |
| EP-0694547-B1 | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivatives | HOFFMANN LA ROCHE (CH) | 1999-04-21 | — | — | EP | disclosed |
| US-5856481-A | Synthesis of antiviral agent valganciclovir (2-(2-amino-1,6-dihydro6-oxo-purin-9-yl)methoxy-3-hydroxy-1-propanyl-L-valinate) or salts via deprotection and salt formation | SYNTEX (U.S.A.) INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5840891-A | VIRICIDES WITH IMPROVED ABSORPTION | SYNTEX (U.S.A.) INC. (US) | 1998-11-24 | — | — | US | disclosed |
| US-5543414-A | VIRICIDES | SYNTEX (USA) INC. (US) | 1996-08-06 | — | — | US | disclosed |
| EP-0694547-A2 | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl)methoxy-1,3-propanediol derivative | F. Hoffmann-La Roche AG (CH) | 1996-01-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020042424-A1 | 2- (2-amino-1, 6-dihydro-6 -oxo-purin-9 -yl) methoxy-1, 3 -propanediol derivative | DPP7, PURB, EIF2AK2 | PDE3A 1270/4885MEN1 850/4885KMT2A 3875/4885 |
| US-20040102462-A1 | 2-(2-amino-1,6-dihydro-6-oxo-purin-9-yl) methoxy-1,3-propanediol derivative | DPP7, PURB, EIF2AK2 | PDE3A 1270/4885MEN1 850/4885KMT2A 3875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.