Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.55 |
| ▸ | ALPI | P09923 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | XIAP | P98170 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.43 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 3/20 | 0.41 |
| ▸ | FNTB | P49356 | 3/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL6753059 | 0.95 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL23924471 | 0.95 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL6276488 | 0.95 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL7089920 | 0.95 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL7751518 | 0.91 | SLC7A5 (0.50) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL14658221 | 0.91 | SLC7A5 (0.56) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL29503517 | 0.89 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL28231547 | 0.89 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL464776 | 0.89 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL28076342 | 0.89 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040081988-A1 | Splice variant isoforms of human calcium channel CACNA1B | ROSETTA INPHARMATICS LLC | 2004-04-29 | — | — | US | disclosed |