Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.61 |
| ▸ | ALPI | P09923 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | XIAP | P98170 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.47 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 3/20 | 0.44 |
| ▸ | FNTB | P49356 | 3/20 | 0.44 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phenylalanine SCHEMBL6276488 | 1.00 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL23924471 | 1.00 | SLC7A5 (0.61) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL6839646 | 0.95 | SLC7A5 (0.55) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL464776 | 0.94 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL28231547 | 0.94 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL29503517 | 0.94 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| Dl-Phenylalanine SCHEMBL28076342 | 0.94 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| Phenylalanine SCHEMBL464777 | 0.94 | SLC7A5 (0.69) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL1585313 | 0.94 | SLC7A5 (0.58) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL28477318 | 0.94 | SLC7A5 (0.58) | SLC7A5ALPIPKMPTGS1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210324027-A1 | MODIFIED INTERLEUKIN-7 PROTEINS AND USES THEREOF | GENEXINE, INC. (KR) | 2021-10-21 | — | — | US | claimed |
| US-20210324027-A1 | MODIFIED INTERLEUKIN-7 PROTEINS AND USES THEREOF | GENEXINE, INC. (KR) | 2021-10-21 | — | — | US | disclosed |
| US-20030097684-A1 | Lipid acyl hydrolases and variants thereof | MAXYGEN, INC. | 2003-05-22 | — | — | US | disclosed |