Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 3/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.37 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 3/20 | 0.33 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27883560 | 0.77 | — | — | |
| SCHEMBL6844699 | 0.72 | F2RL1 (0.49) | NISCHMTORADKMEN1ALDH1A1 | |
| SCHEMBL2073936 | 0.70 | F2RL1 (0.44) | NISCHMTORADKMEN1ALDH1A1 | |
| SCHEMBL81650 | 0.66 | NISCH (0.59) | NISCHMTORADKMEN1ALDH1A1 | |
| SCHEMBL21672054 | 0.66 | DYRK1A (0.47) | PIK3CDPIK3CAMTORDYRK1APIK3CB | |
| SCHEMBL30877484 | 0.66 | PIK3CD (0.35) | PIK3CDPIK3CAMAPK14CSNK1ECSNK1D | |
| SCHEMBL1205638 | 0.65 | — | — | |
| SCHEMBL14334928 | 0.64 | HRH3 (0.53) | DYRK1AADRA2A | |
| SCHEMBL1303873 | 0.64 | PIK3CD (0.37) | PIK3CDPIK3CADYRK1AMAPK14CSNK1E | |
| SCHEMBL1461133 | 0.64 | NISCH (0.39) | NISCHMTORADKMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |