Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.68 |
| ▸ | POLA1 | P09884 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | F2 | P00734 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6283191 | 0.93 | KCNH2 (0.66) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6288993 | 0.90 | KCNH2 (0.61) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6280316 | 0.85 | KCNH2 (0.67) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6789243 | 0.84 | POLA1 (0.69) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6698737 | 0.84 | POLA1 (0.69) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6734926 | 0.84 | POLA1 (0.60) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6813447 | 0.84 | KCNH2 (0.69) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6814213 | 0.84 | KCNH2 (0.67) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6281183 | 0.83 | KCNH2 (0.71) | KCNH2POLA1MEN1KMT2AF2 | |
| SCHEMBL6725093 | 0.83 | POLA1 (0.58) | KCNH2POLA1MEN1KMT2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040176366-A1 | Method of preventing or treating atherosclerosis or restenosis | WATHEN MICHAEL W | 2004-09-09 | — | — | US | claimed |
| US-20040142928-A1 | Heterocycle carboxamides as antiviral agents | BUNDY GORDON L (US) | 2004-07-22 | — | — | US | claimed |
| US-20030207880-A1 | Heterocycle carboxamides as antiviral agents | BUNDY GORDON L (US) | 2003-11-06 | — | — | US | claimed |
| US-6559145-B2 | Herpes virus | PHARMACIA & UPJOHN COMPANY | 2003-05-06 | — | — | US | claimed |
| US-20020025960-A1 | Heterocycle carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-02-28 | — | — | US | claimed |
| US-20040176366-A1 | Method of preventing or treating atherosclerosis or restenosis | WATHEN MICHAEL W | 2004-09-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176366-A1 | Method of preventing or treating atherosclerosis or restenosis | LDLR, NR1H3, NR1H2 | KCNH2 4095/4885POLA1 2447/4885MEN1 2651/4885 |
| US-20040142928-A1 | Heterocycle carboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, HDAC1 | KCNH2 919/4885POLA1 267/4885MEN1 2250/4885 |
| US-20020025960-A1 | Heterocycle carboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, HDAC1 | KCNH2 919/4885POLA1 267/4885MEN1 2250/4885 |
| US-20030207880-A1 | Heterocycle carboxamides as antiviral agents | ZC3HAV1, ZC3HAV1L, HDAC1 | KCNH2 919/4885POLA1 267/4885MEN1 2250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.