Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Glycerin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycerin SCHEMBL8537586 | 0.92 | LMNA (0.53) | LMNAALDH1A1OR51E2KDM4EDUSP3 | |
| Glycerin SCHEMBL2480100 | 0.91 | LMNA (0.60) | LMNAALDH1A1OR51E2ACHESLC22A6 | |
| Glycerin SCHEMBL8107234 | 0.91 | LMNA (0.60) | LMNAALDH1A1OR51E2ACHESLC22A6 | |
| Glycerin SCHEMBL30552142 | 0.91 | LMNA (0.60) | LMNAALDH1A1OR51E2ACHESLC22A6 | |
| Glycerin SCHEMBL1357085 | 0.88 | LMNA (0.56) | LMNAALDH1A1OR51E2ACHESLC22A6 | |
| Glycerin SCHEMBL20504374 | 0.88 | LMNA (0.56) | LMNAALDH1A1OR51E2KDM4EDUSP3 | |
| Glycerin SCHEMBL28872893 | 0.88 | LMNA (0.56) | LMNAALDH1A1OR51E2ACHESLC22A6 | |
| Glycerin SCHEMBL4451001 | 0.86 | LMNA (0.53) | LMNAALDH1A1OR51E2ACHESLC22A6 | |
| Glycerin SCHEMBL23675030 | 0.86 | LMNA (0.53) | LMNAALDH1A1OR51E2KDM4EDUSP3 | |
| Glycerin SCHEMBL27617095 | 0.86 | LMNA (0.53) | LMNAALDH1A1OR51E2KDM4EDUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040249098-A1 | (Meth)acrylic and (meth)acrylamide monomers comprising cyclic acetal/thioacetal groups, polymerizable compositions, and polymers obtained | THE REGENTS OF THE UNIVERSITY OF COLORADO | 2004-12-09 | — | — | US | disclosed |