Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TYMP | P19971 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 4/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | PAX3 | P23760 | 1/20 | 0.34 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7534659 | 0.86 | KDM4E (0.49) | KDM4ETYMPTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL2113125 | 0.86 | KDM4E (0.49) | KDM4ETYMPTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL441421 | 0.84 | TYMP (0.48) | KDM4ETYMPTAS1R3TAS1R1TAAR1 | |
| SCHEMBL4553693 | 0.82 | KDM4E (0.51) | KDM4ETYMPTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL9116775 | 0.82 | KDM4E (0.42) | KDM4ETYMPTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL5963306 | 0.81 | TYMP (0.44) | KDM4ETYMPTAS1R3TAS1R1PDE9A | |
| SCHEMBL9294603 | 0.81 | TYMP (0.44) | KDM4ETYMPTAS1R3TAS1R1PDE9A | |
| SCHEMBL11281236 | 0.81 | KDM4E (0.46) | KDM4ETYMPTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL21065504 | 0.80 | TYMP (0.47) | KDM4ETYMPTAS1R3TAS1R1SMN1; SMN2 | |
| SCHEMBL6839735 | 0.80 | ADORA2A (0.43) | TYMP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756496-B1 | SUCH AS TRIETHYLAMMONIUM-5'-DIMETHOXYTRITYL-3'-THYMIDINE-HYDROGEN PHOSPHONONDITHIOATE FOR USE AS ANTIVIRAL AND ANTICANCER AGENTS | ISIS PHARMACEUTICALS, INC. | 2004-06-29 | — | — | US | claimed |
| EP-0360609-A2 | Novel hydrogen phosphonodithioate compositions | GILEAD SCIENCES, INC. (US) | 1990-03-28 | — | — | EP | claimed |