Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | NPC1 | O15118 | 4/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6560025 | 0.84 | KMT2A (0.66) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL8358105 | 0.78 | TP53 (0.83) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL29826604 | 0.78 | TP53 (0.83) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL8703993 | 0.78 | NPC1 (0.72) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL15583956 | 0.77 | KMT2A (0.60) | KMT2AMEN1MAPTGAAALDH1A1 | |
| SCHEMBL18101487 | 0.77 | KMT2A (0.66) | KMT2AMEN1MAPTMAPK1GAA | |
| Hydrochloric Acid SCHEMBL10570595 | 0.77 | NPC1 (0.70) | KMT2AMEN1NPC1RAB9AMAPT | |
| SCHEMBL1520429 | 0.75 | TDP1 (0.72) | KMT2AMAPTMAPK1TP53GAA | |
| SCHEMBL30691740 | 0.75 | HDAC8 (0.60) | KMT2AMEN1MAPTMAPK1GAA | |
| SCHEMBL9424289 | 0.75 | NPC1 (0.68) | KMT2AMEN1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202992-B1 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | CEPHALON FRANCE (FR) | 2004-09-15 | — | — | EP | disclosed |
| EP-1202992-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012631-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |