Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.69 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 1/20 | 0.60 |
| ▸ | PRKX | P51817 | 1/20 | 0.60 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8260543 | 0.86 | KDM4E (0.60) | PARP1DHODH | |
| SCHEMBL1193115 | 0.85 | PARP1 (0.54) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL16497016 | 0.83 | PARP1 (0.69) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL1933246 | 0.83 | PARP1 (0.69) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL871829 | 0.81 | PARP1 (1.00) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL24112332 | 0.81 | PKN1 (0.61) | PARP1PKN1PKN2 | |
| SCHEMBL1202374 | 0.81 | PKN1 (0.61) | PARP1PKN1PKN2 | |
| SCHEMBL25022851 | 0.79 | PARP1 (0.63) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL7316597 | 0.79 | PARP1 (1.00) | PARP1PKN1PKN2PLK4MAPK13 | |
| SCHEMBL6842025 | 0.78 | PARP1 (0.66) | PARP1PKN1PKN2PLK4MAPK13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7635695-B2 | Antiinflammation agents | AMGEN INC. (US) | 2009-12-22 | — | — | US | disclosed |
| US-20070155777-A1 | Antiinflammation agents | AMGEN, INC. | 2007-07-05 | — | — | US | disclosed |
| US-20070155777-A1 | Antiinflammation agents | AMGEN, INC. | 2007-07-05 | — | — | US | disclosed |
| US-7199119-B2 | Antiinflammation agents | AMGEN INC. (US) | 2007-04-03 | — | — | US | disclosed |
| US-7199119-B2 | Antiinflammation agents | AMGEN INC. (US) | 2007-04-03 | — | — | US | disclosed |
| US-20040034078-A1 | Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase | AGOURON PHARMACEUTICALS, INC. | 2004-02-19 | — | — | US | disclosed |
| WO-2003106430-A1 | BENZIMIDAZOLE INHIBITORS OF POLY(ADP-RIBOSYL) POLYMERASE | PFIZER INC. (US) | 2003-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034078-A1 | Benzimidazole inhibitors of poly(ADP-ribosyl) polymerase | PARP1, PARP11, PARP2 | PARP1 1/4885PKN1 742/4885PKN2 838/4885 |
| US-20070155777-A1 | Antiinflammation agents | TNF, NFATC1, NFKBIA | PARP1 1545/4885PKN1 3194/4885PKN2 3546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.