Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.69 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.61 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.60 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.60 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.60 |
| ▸ | PIM1 | P11309 | 1/20 | 0.60 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.60 |
| ▸ | PRKACA | P17612 | 1/20 | 0.60 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.60 |
| ▸ | CLK2 | P49760 | 1/20 | 0.60 |
| ▸ | GSK3A | P49840 | 1/20 | 0.60 |
| ▸ | PRKX | P51817 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2127145 | 0.85 | PKN1 (0.59) | PARP1PARP2PKN1PKN2 | |
| SCHEMBL3726213 | 0.83 | CHEK1 (0.49) | PARP1PARP2PKN1PKN2PLK4 | |
| SCHEMBL16497016 | 0.83 | PARP1 (0.69) | PARP1PARP2PKN1PKN2PLK4 | |
| SCHEMBL6842051 | 0.83 | PARP1 (0.69) | PARP1PARP2PKN1PKN2PLK4 | |
| SCHEMBL4629094 | 0.83 | PARP1 (0.47) | PARP1PARP2PKN1PKN2PLK4 | |
| SCHEMBL871829 | 0.81 | PARP1 (1.00) | PARP1PARP2PKN1PKN2PLK4 | |
| SCHEMBL20479886 | 0.81 | PARP1 (0.46) | PARP1PARP2PKN1PKN2PLK4 | |
| SCHEMBL3137529 | 0.81 | HRH4 (0.58) | PARP1 | |
| SCHEMBL25022851 | 0.79 | PARP1 (0.63) | PARP1PARP2PKN1PKN2PLK4 | |
| SCHEMBL20479692 | 0.79 | PARP1 (0.51) | PARP1PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778675-A1 | CHIRAL PYRROLIDINE DERIVATIVES, AND METHODS FOR PREPARING COMPOUNDS THEREOF | Cylene Pharmaceuticals, Inc. (US) | 2007-05-02 | — | — | EP | claimed |
| WO-2006015150-A1 | CHIRAL PYRROLIDINE DERIVATIVES, AND METHODS FOR PREPARING COMPOUNDS THEREOF | CYLENE PHARMACEUTICALS (US) | 2006-02-09 | — | — | WO | claimed |
| EP-2506837-B1 | SPIDER SILK PARTICLES FOR CONTROLLED AND SUSTAINED DELIVERY OF COMPOUNDS | AMSILK GMBH (DE) | 2020-07-01 | — | — | EP | disclosed |
| EP-2654418-B1 | AGRICULTURAL COMPOSITION COMPRISING PH SENSITIVE AGRICULTURAL CHEMICALS AND ORGANIC PH BUFFER | NUTRIAG LTD (CA) | 2017-08-23 | — | — | EP | disclosed |
| US-9277747-B2 | Agricultural composition comprising pH sensitive agricultural chemicals and organic pH buffer | NUTRIAG LTD. (CA) | 2016-03-08 | — | — | US | disclosed |
| US-9233067-B2 | Silk particles for controlled and sustained delivery of compounds | AMSILK GMBH (DE) | 2016-01-12 | — | — | US | disclosed |
| EP-2654418-A1 | AGRICULTURAL COMPOSITION COMPRISING PH SENSITIVE AGRICULTURAL CHEMICALS AND ORGANIC PH BUFFER | Nutriag Ltd. (CA) | 2013-10-30 | — | — | EP | disclosed |
| US-20130109762-A1 | SILK PARTICLES FOR CONTROLLED AND SUSTAINED DELIVERY OF COMPOUNDS | AMSILK GMBH (DE) | 2013-05-02 | — | — | US | disclosed |
| EP-2506837-A2 | SPIDER SILK PARTICLES FOR CONTROLLED AND SUSTAINED DELIVERY OF COMPOUNDS | Amsilk GmbH (DE) | 2012-10-10 | — | — | EP | disclosed |
| WO-2012083453-A1 | AGRICULTURAL COMPOSITION COMPRISING PH SENSITIVE AGRICULTURAL CHEMICALS AND ORGANIC PH BUFFER | NUTRIAG LTD. (CA) | 2012-06-28 | — | — | WO | disclosed |
| US-20120157317-A1 | AGRICULTURAL COMPOSITION COMPRISING PH SENSITIVE AGRICULTURAL CHEMICALS AND ORGANIC PH BUFFER | NUTRIAG LTD (CA) | 2012-06-21 | — | — | US | disclosed |
| WO-2006015150-A1 | CHIRAL PYRROLIDINE DERIVATIVES, AND METHODS FOR PREPARING COMPOUNDS THEREOF | CYLENE PHARMACEUTICALS (US) | 2006-02-09 | — | — | WO | disclosed |
| US-20040214821-A1 | Useful in the treatment of allergy and/or asthma or any diseases where Immunoglobulin E (IgE) is pathogenic; anticancer agents | SIRCAR JAGADISH C (US) | 2004-10-28 | — | — | US | disclosed |
| US-6759425-B2 | USEFUL IN THE TREATMENT OF ALLERGY AND/OR ASTHMA OR ANY DISEASES WHERE IGE IS PATHOGENIC; ALSO ARE USEFUL AS ANTICANCER AGENTS. | AVANIR PHARMACEUTICALS | 2004-07-06 | — | — | US | disclosed |
| EP-1368028-A1 | BENZIMIDAZOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002072090-A1 | BENZIMIDAZOLE COMPOUNDS FOR MODULATING IGE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2002-09-19 | — | — | WO | disclosed |
| US-20020132808-A1 | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS | 2002-09-19 | — | — | US | disclosed |
| US-5514639-A | COLORING | GOUWS & SCHEEPERS (PROPRIETARY) LIMITED (ZA) | 1996-05-07 | — | — | US | disclosed |
| US-5278132-A | PH color indicator for acidity water | GOUWS & SCHEEPERS (PROPIETARY) LTD. (ZA) | 1994-01-11 | — | — | US | disclosed |
| US-5216003-A | Antihypoxic, antiischemic agents | G. D. SEARLE & CO. (US) | 1993-06-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040214821-A1 | Useful in the treatment of allergy and/or asthma or any diseases where Immunoglobulin E (IgE) is pathogenic; anticancer agents | FCER2, CMA1, FCGR1A | PARP1 1241/4885PARP2 1308/4885PKN1 2256/4885 |
| US-20020132808-A1 | Benzimidazole compounds for modulating IgE and inhibiting cellular proliferation | MKI67, CMA1, CCNI | PARP1 762/4885PARP2 916/4885PKN1 1746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.