Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.46 |
| ▸ | HRH2 | P25021 | 13/20 | 0.46 |
| ▸ | HRH1 | P35367 | 13/20 | 0.46 |
| ▸ | NSD2 | O96028 | 1/20 | 0.43 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP3 | P08254 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6982371 | 0.91 | HRH3 (0.46) | HRH3HRH2HRH1NSD2MMP2 | |
| SCHEMBL6842171 | 0.86 | HRH3 (0.49) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL6987517 | 0.82 | HRH3 (0.48) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL7134601 | 0.81 | HRH2 (0.46) | HRH3HRH2HRH1PRKAA2MMP3 | |
| SCHEMBL6978713 | 0.79 | HRH3 (0.50) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL6983478 | 0.77 | HRH3 (0.48) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL6985772 | 0.76 | HRH3 (0.47) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL6986426 | 0.76 | HRH2 (0.49) | HRH3HRH2HRH1MMP2MMP3 | |
| SCHEMBL6987544 | 0.74 | HRH2 (0.43) | HRH3HRH2HRH1 | |
| SCHEMBL5213985 | 0.74 | HRH3 (0.57) | HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467727-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | Abbott Laboratories (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059341-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-07-24 | — | — | WO | disclosed |
| EP-1301480-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-04-16 | — | — | EP | disclosed |
| WO-2002006223-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-01-24 | — | — | WO | disclosed |