Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 15/20 | 0.49 |
| ▸ | HRH1 | P35367 | 15/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MMP3 | P08254 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7134601 | 0.95 | HRH2 (0.46) | HRH2HRH1HRH3CHRM4GAA | |
| SCHEMBL6842225 | 0.92 | HRH2 (0.59) | HRH2HRH1HRH3GAA | |
| SCHEMBL6984761 | 0.89 | HRH2 (0.49) | HRH2HRH1HRH3MMP3HDAC1 | |
| SCHEMBL6847378 | 0.88 | HRH2 (0.46) | HRH2HRH1HRH3 | |
| SCHEMBL6987144 | 0.86 | HRH3 (0.49) | HRH2HRH1HRH3MMP3HDAC1 | |
| SCHEMBL6986434 | 0.86 | HRH3 (0.46) | HRH2HRH1HRH3CHRM4MMP3 | |
| SCHEMBL6983118 | 0.84 | HRH3 (0.46) | HRH2HRH1HRH3MMP3HDAC1 | |
| SCHEMBL6980404 | 0.84 | HRH3 (0.50) | HRH2HRH1HRH3MMP3 | |
| SCHEMBL6985870 | 0.82 | HRH2 (0.47) | HRH2HRH1HRH3 | |
| SCHEMBL6981316 | 0.79 | HRH2 (0.44) | HRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-04-16 | — | — | EP | claimed |
| WO-2002006223-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-01-24 | — | — | WO | claimed |