Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 3/20 | 0.45 |
| ▸ | PLK1 | P53350 | 9/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 5/20 | 0.39 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.35 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | STK4 | Q13043 | 1/20 | 0.34 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.34 |
| ▸ | PIP4K2B | P78356 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840359 | 0.97 | PRKDC (0.45) | PRKDCPLK1BRD4BRDTPIK3CD | |
| SCHEMBL2875624 | 0.95 | PRKDC (0.47) | PRKDCPLK1BRD4BRDTPIK3CD | |
| SCHEMBL30030718 | 0.89 | PRKDC (0.57) | PRKDCPLK1BRD4BRDTPIK3CD | |
| SCHEMBL6844511 | 0.89 | PRKDC (0.57) | PRKDCPLK1BRD4BRDTPIK3CD | |
| SCHEMBL3546382 | 0.87 | PLK1 (0.51) | PRKDCPLK1BRD4BRDTALK | |
| SCHEMBL6840457 | 0.86 | PRKDC (0.49) | PRKDCPLK1BRD4BRDTPIK3CD | |
| SCHEMBL1203651 | 0.85 | PLK1 (0.53) | PRKDCPLK1BRD4BRDTALK | |
| SCHEMBL30135828 | 0.85 | PLK1 (0.53) | PRKDCPLK1BRD4BRDTALK | |
| SCHEMBL3537772 | 0.84 | PLK1 (0.52) | PLK1BRD4BRDTALKTTK | |
| SCHEMBL6844719 | 0.84 | PRKDC (0.39) | PRKDCPLK1BRD4BRDTPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079114-A1 | PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |