Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 3/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PLK1 | P53350 | 4/20 | 0.35 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 2/20 | 0.34 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.34 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | STK4 | Q13043 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844602 | 0.91 | PRKDC (0.39) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2875624 | 0.86 | PRKDC (0.47) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6844709 | 0.85 | PRKDC (0.39) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6844375 | 0.84 | PRKDC (0.45) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6840359 | 0.84 | PRKDC (0.45) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30030718 | 0.81 | PRKDC (0.57) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL6844511 | 0.81 | PRKDC (0.57) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16405158 | 0.78 | PLK2 (0.40) | PRKDCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16405157 | 0.77 | PLK1 (0.44) | PLK1PLK2BRD4BRDTRPS6KA3 | |
| SCHEMBL2874984 | 0.77 | RPS6KA3 (0.36) | PRKDCSMN1; SMN2RPS6KA3STK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |