Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 5/20 | 0.44 |
| ▸ | PLK2 | Q9NYY3 | 5/20 | 0.44 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844528 | 0.80 | PLK1 (0.43) | PLK1PLK2PLK3 | |
| SCHEMBL2345380 | 0.79 | PLK1 (0.72) | PLK1PLK2PLK3 | |
| SCHEMBL2341982 | 0.79 | PLK1 (0.72) | PLK1PLK2PLK3 | |
| SCHEMBL2341976 | 0.79 | PLK1 (0.72) | PLK1PLK2PLK3 | |
| SCHEMBL16405244 | 0.73 | PLK1 (0.60) | PLK1PLK2PLK3 | |
| SCHEMBL6840481 | 0.72 | PLK2 (0.45) | PLK1PLK2PLK3 | |
| SCHEMBL6840403 | 0.70 | STK4 (0.38) | PLK1PLK2PLK3 | |
| SCHEMBL2874984 | 0.69 | RPS6KA3 (0.36) | — | |
| SCHEMBL6844422 | 0.68 | STK4 (0.36) | PLK1PLK2PLK3 | |
| SCHEMBL2689588 | 0.68 | PLK1 (0.49) | PLK1PLK2PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |