Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK4 | Q13043 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.33 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 5/20 | 0.31 |
| ▸ | AOC1 | P19801 | 2/20 | 0.30 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6840403 | 0.86 | STK4 (0.38) | STK4RPS6KA3PLK1PLK2PLK3 | |
| SCHEMBL6844502 | 0.85 | STK4 (0.37) | STK4RPS6KA3PLK1PLK2PLK3 | |
| SCHEMBL6844424 | 0.85 | CYP11B2 (0.35) | STK4RPS6KA3PLK1PLK2PLK3 | |
| SCHEMBL7742264 | 0.83 | KCNA5 (0.34) | STK4RPS6KA3 | |
| SCHEMBL6840522 | 0.79 | USP1 (0.35) | STK4RPS6KA3USP1 | |
| SCHEMBL6840386 | 0.78 | STK4 (0.34) | STK4RPS6KA3PLK1 | |
| SCHEMBL2032070 | 0.77 | PLK1 (0.56) | STK4PLK1PLK2PLK3 | |
| SCHEMBL2032071 | 0.77 | PLK1 (0.56) | STK4PLK1PLK2PLK3 | |
| SCHEMBL2029784 | 0.71 | PLK1 (0.54) | PLK1PLK2PLK3 | |
| SCHEMBL2029787 | 0.71 | PLK1 (0.54) | PLK1PLK2PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |