Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051024 | 0.85 | MAPT (0.41) | MAPTSMN1; SMN2LMNAXBP1ATM | |
| SCHEMBL4516672 | 0.75 | TSHR (0.43) | MAPTSMN1; SMN2LMNAXBP1ATM | |
| SCHEMBL15689787 | 0.74 | TDP1 (0.46) | MAPTSMN1; SMN2LMNATSHRTDP1 | |
| SCHEMBL13341652 | 0.74 | CES1 (0.44) | MAPTSMN1; SMN2TSHRTDP1CYP2C19 | |
| SCHEMBL4900468 | 0.74 | TDP1 (0.46) | MAPTSMN1; SMN2LMNATSHRTDP1 | |
| SCHEMBL28825945 | 0.74 | CES1 (0.44) | MAPTSMN1; SMN2TSHRTDP1CYP2C19 | |
| SCHEMBL4560875 | 0.71 | CES1 (0.45) | MAPTSMN1; SMN2LMNAATMNPSR1 | |
| SCHEMBL791662 | 0.70 | CES1 (0.44) | MAPTSMN1; SMN2LMNAATMTSHR | |
| SCHEMBL6384300 | 0.70 | MAPT (0.45) | MAPTSMN1; SMN2LMNAXBP1ATM | |
| SCHEMBL791663 | 0.70 | CES1 (0.44) | MAPTSMN1; SMN2LMNAATMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079114-A1 | PTERIDINONES AS INHIBITORS OF POLO - LIKE KINASE | ELAN PHARMACEUTICALS, INC. (US) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |