Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | XBP1 | P17861 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CES2 | O00748 | 3/20 | 0.39 |
| ▸ | CES1 | P23141 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844490 | 0.85 | MAPT (0.39) | MAPTSMN1; SMN2LMNAXBP1ATM | |
| SCHEMBL28402297 | 0.79 | ALDH1A1 (0.49) | MAPTSMN1; SMN2LMNAALDH1A1NPC1 | |
| SCHEMBL13341652 | 0.77 | CES1 (0.44) | MAPTSMN1; SMN2ALDH1A1CES2CES1 | |
| SCHEMBL28825945 | 0.77 | CES1 (0.44) | MAPTSMN1; SMN2ALDH1A1CES2CES1 | |
| SCHEMBL4560875 | 0.73 | CES1 (0.45) | MAPTSMN1; SMN2LMNAATMNPSR1 | |
| SCHEMBL791663 | 0.72 | CES1 (0.44) | MAPTSMN1; SMN2LMNAATMALDH1A1 | |
| SCHEMBL4900468 | 0.72 | TDP1 (0.46) | MAPTSMN1; SMN2LMNAALDH1A1CES2 | |
| SCHEMBL791662 | 0.72 | CES1 (0.44) | MAPTSMN1; SMN2LMNAATMALDH1A1 | |
| SCHEMBL15689787 | 0.72 | TDP1 (0.46) | MAPTSMN1; SMN2LMNAALDH1A1CES2 | |
| SCHEMBL6384300 | 0.72 | MAPT (0.45) | MAPTSMN1; SMN2LMNAXBP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009075778-A2 | NONPEPTIDIC INHIBITORS OF CRUZAIN | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-06-18 | — | — | WO | disclosed |