Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK2 | Q9NYY3 | 18/20 | 0.38 |
| ▸ | PLK1 | P53350 | 15/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844378 | 0.86 | PLK2 (0.40) | PLK2PLK1PLK3 | |
| SCHEMBL2050617 | 0.85 | PLK2 (0.46) | PLK2PLK1PLK3 | |
| SCHEMBL2050615 | 0.85 | PLK2 (0.46) | PLK2PLK1PLK3 | |
| SCHEMBL6844619 | 0.85 | PLK2 (0.41) | PLK2PLK1PLK3 | |
| SCHEMBL6844455 | 0.83 | PLK2 (0.36) | PLK2PLK1PLK3 | |
| SCHEMBL2688167 | 0.80 | PLK2 (0.36) | PLK2PLK1PLK3ALDH1A1HSD17B10 | |
| SCHEMBL1688498 | 0.80 | PLK2 (0.38) | PLK2PLK1PLK3ALDH1A1HSD17B10 | |
| SCHEMBL6844673 | 0.80 | PLK2 (0.44) | PLK2PLK1PLK3 | |
| SCHEMBL6844588 | 0.79 | PLK1 (0.33) | PLK2PLK1PLK3 | |
| SCHEMBL6844581 | 0.78 | PLK2 (0.38) | PLK2PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079118-A1 | PTERIDINONES AS INHIBITORS OF POLO-LIKE KINASE | ELAN PHARMACEUTICALS, INC (US) | 2011-06-30 | — | — | WO | disclosed |