Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.32 |
| ▸ | TUBB | P07437 | 2/20 | 0.32 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.32 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.32 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.32 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.32 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.32 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.32 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.32 |
| ▸ | TUBA3E | Q6PEY2 | 2/20 | 0.32 |
| ▸ | TUBA1A | Q71U36 | 2/20 | 0.32 |
| ▸ | TUBA1C | Q9BQE3 | 2/20 | 0.32 |
| ▸ | TUBB6 | Q9BUF5 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18801333 | 0.92 | METAP2 (0.43) | METAP2FABP4FABP5BRD4ALDH1A1 | |
| SCHEMBL14717710 | 0.92 | METAP2 (0.43) | METAP2FABP4FABP5BRD4ALDH1A1 | |
| SCHEMBL1648565 | 0.92 | METAP2 (0.43) | METAP2FABP4FABP5BRD4ALDH1A1 | |
| SCHEMBL1648087 | 0.88 | METAP2 (0.55) | METAP2FABP4FABP5BRD4PPARG | |
| SCHEMBL1648085 | 0.88 | METAP2 (0.55) | METAP2FABP4FABP5BRD4PPARG | |
| SCHEMBL16863810 | 0.88 | METAP2 (0.55) | METAP2FABP4FABP5BRD4PPARG | |
| SCHEMBL6844943 | 0.86 | METAP2 (0.39) | METAP2FABP4FABP5ALDH1A1 | |
| SCHEMBL1648099 | 0.86 | METAP2 (0.45) | METAP2FABP4FABP5BRD4ALDH1A1 | |
| SCHEMBL1648337 | 0.86 | METAP2 (0.43) | METAP2FABP4FABP5BRD4ALDH1A1 | |
| SCHEMBL1648274 | 0.85 | METAP2 (0.46) | METAP2FABP4FABP5BRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |