Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL313106 | 0.90 | MAPT (0.38) | MAPTKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL6844946 | 0.77 | PDE10A (0.39) | MAPTKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL313767 | 0.74 | MAPT (0.39) | MAPTKDM4EPOLBALDH1A1LMNA | |
| SCHEMBL10271218 | 0.72 | PDE10A (0.34) | MAPTKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL8135887 | 0.71 | PDE10A (0.34) | MAPTPOLBSMN1; SMN2NPC1RAB9A | |
| SCHEMBL314529 | 0.70 | KDM4E (0.38) | MAPTKDM4EPOLBATMALDH1A1 | |
| SCHEMBL13637183 | 0.70 | MAPT (0.42) | MAPTKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL312965 | 0.69 | CSF1R (0.43) | MAPTKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL3625504 | 0.69 | MAPT (0.40) | MAPTKDM4EPOLBALDH1A1HPGD | |
| SCHEMBL13090548 | 0.69 | MAPT (0.40) | MAPTKDM4EPOLBALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011017389-A1 | MACROCYCLIC SERINE PROTEASE INHIBITORS USEFUL AGAINST VIRAL INFECTIONS, PARTICULARLY HCV | IDENIX PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | disclosed |