Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13637183 | 0.88 | MAPT (0.42) | MAPTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL313767 | 0.88 | MAPT (0.39) | MAPTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL12070947 | 0.86 | KDM4E (0.41) | MAPTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL313693 | 0.86 | CTSS (0.38) | MAPTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL312942 | 0.85 | ALDH1A1 (0.35) | MAPTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL1232405 | 0.85 | ALDH1A1 (0.35) | MAPTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL3671740 | 0.85 | FPR2 (0.37) | MAPTRAB9ASMN1; SMN2NPC1POLB | |
| SCHEMBL7917644 | 0.84 | SREBF2 (0.41) | MAPTRAB9ASMN1; SMN2POLBALDH1A1 | |
| SCHEMBL996348 | 0.82 | SMPD3 (0.47) | MAPTRAB9ASMN1; SMN2NPC1GAA | |
| SCHEMBL13637184 | 0.81 | CYP3A4 (0.39) | MAPTRAB9ASMN1; SMN2NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033466-A1 | MACROCYCLIC INHIBITORS OF HEPATITIS C PROTEASE | PHENOMIX CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |
| WO-2009142842-A2 | NOVEL MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS REPLICATION | INTERMUNE, INC. (US) | 2009-11-26 | — | — | WO | disclosed |