Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 10/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.59 |
| ▸ | NEK2 | P51955 | 7/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2322669 | 0.73 | ROCK2 (0.72) | ROCK2ROCK1NEK2 | |
| SCHEMBL2321088 | 0.73 | ROCK2 (0.87) | ROCK2ROCK1NEK2 | |
| SCHEMBL12439974 | 0.70 | ROCK2 (1.00) | ROCK2ROCK1NEK2 | |
| Hydrochloric Acid SCHEMBL2320003 | 0.70 | ROCK2 (0.98) | ROCK2ROCK1NEK2 | |
| SCHEMBL2325042 | 0.69 | ROCK2 (0.75) | ROCK2ROCK1NEK2 | |
| SCHEMBL2321462 | 0.69 | ROCK2 (0.71) | ROCK2ROCK1NEK2 | |
| SCHEMBL988824 | 0.67 | ROCK2 (0.69) | ROCK2ROCK1 | |
| SCHEMBL3513029 | 0.66 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL2323120 | 0.66 | ROCK2 (0.65) | ROCK2ROCK1NEK2 | |
| SCHEMBL2321276 | 0.65 | ROCK2 (0.67) | ROCK2ROCK1NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |