Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.71 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | NT5E | P21589 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | JAK2 | O60674 | 1/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | STAT3 | P40763 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30192651 | 0.86 | ROCK2 (0.77) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| SCHEMBL5460526 | 0.84 | ROCK2 (0.75) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| SCHEMBL1554113 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| SCHEMBL1553349 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| SCHEMBL1553353 | 0.83 | ROCK2 (1.00) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| SCHEMBL6558035 | 0.82 | ROCK2 (0.67) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| SCHEMBL6558041 | 0.82 | ROCK2 (0.67) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL1770829 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL2474313 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1KDM4EL3MBTL1KMT2A | |
| Hydrochloric Acid SCHEMBL1770831 | 0.82 | ROCK2 (1.00) | ROCK2ROCK1KDM4EL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |