Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.53 |
| ▸ | CTSD | P07339 | 2/20 | 0.53 |
| ▸ | CTSE | P14091 | 1/20 | 0.53 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6845485 | 0.76 | BACE1 (0.46) | BACE1CTSD | |
| SCHEMBL12236586 | 0.73 | BACE1 (0.61) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL12236617 | 0.71 | BACE1 (0.63) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL570562 | 0.71 | BACE1 (0.71) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL571397 | 0.71 | BACE1 (0.71) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL570925 | 0.71 | BACE1 (0.71) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL571238 | 0.71 | BACE1 (0.71) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL2382805 | 0.69 | BACE1 (1.00) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL2370582 | 0.69 | BACE1 (0.71) | BACE1CTSDCTSEBACE2 | |
| SCHEMBL2524148 | 0.69 | BACE1 (0.83) | BACE1CTSDCTSEBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011115928-A1 | AMINO -DIHYDROOXAZINE AND AMINO - DIHYDROTHIAZINE SPIRO COMPOUNDS AS BETA - SECRETASE MODULATORS AND THEIR MEDICAL USE | AMGEN INC. (US) | 2011-09-22 | — | — | WO | disclosed |