Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.58 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.57 |
| ▸ | ANPEP | P15144 | 2/20 | 0.50 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 2/20 | 0.46 |
| ▸ | LAP3 | P28838 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8761734 | 1.00 | EPHX1 (0.58) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| SCHEMBL7758242 | 1.00 | EPHX1 (0.58) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| SCHEMBL7340766 | 1.00 | EPHX1 (0.58) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| Hydrochloric Acid SCHEMBL27559410 | 0.98 | EPHX1 (0.56) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| SCHEMBL6425554 | 0.87 | EPHX1 (0.62) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| SCHEMBL9394032 | 0.86 | CSNK1E (0.49) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| Hydrochloric Acid SCHEMBL9388352 | 0.85 | EPHX1 (0.60) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| SCHEMBL4502384 | 0.83 | EPHX1 (0.58) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| SCHEMBL11091491 | 0.83 | EPHX1 (0.58) | EPHX1CSNK1EANPEPSLC15A1ALPI | |
| SCHEMBL296417 | 0.83 | EPHX1 (0.52) | EPHX1CSNK1EANPEPSLC15A1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0827507-B1 | PROTEASE INHIBITING SUCCINIC ACID DERIVATIVES | BOEHRINGER INGELHEIM CA LTD (CA) | 1999-06-16 | — | — | EP | claimed |
| JP-10152459-A | — | — | None | — | — | JP | disclosed |
| EP-1509537-B9 | CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH | GILEAD SCIENCES INC (US) | 2007-11-14 | — | — | EP | disclosed |
| EP-1509537-B1 | CELLULAR ACCUMULATION OF PHOSPHONATE ANALOGS OF HIV PROTEASE INHIBITOR COMPOUNDS AND THE COMPOUNDS AS SUCH | GILEAD SCIENCES INC (US) | 2007-07-18 | — | — | EP | disclosed |
| US-20040267022-A1 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | G. D. SEARLE & CO. | 2004-12-30 | — | — | US | disclosed |
| EP-0769003-B1 | AMINO ACID-DERIVED DIAMINOPROPANOLS | PHARMECO LAB INC (US) | 2001-05-16 | — | — | EP | disclosed |
| EP-1059285-A2 | Process for the preparation of 1,3-diamino-2-propanol and 1,3-diamino-2-propanone derivatives | Pharm-Eco Laboratories, Inc. (US) | 2000-12-13 | — | — | EP | disclosed |
| US-6063963-A | Amino acid-derived diaminopropanols | PHARM-ECO LABORATORIES, INC. (US) | 2000-05-16 | — | — | US | disclosed |
| EP-0827507-B1 | PROTEASE INHIBITING SUCCINIC ACID DERIVATIVES | BOEHRINGER INGELHEIM CA LTD (CA) | 1999-06-16 | — | — | EP | disclosed |
| JP-H10152459-A | PRODUCTION OF 1,3-DIAMINO-4-PHENYL-2-BUTANOL DERIVATIVE, ITS PRODUCTION INTERMEDIATE AND ITS PRODUCTION | SAGAMI CHEM RES CENTER | 1998-06-09 | — | — | JP | disclosed |
| US-5631405-A | Method of forming amino acid-derived diaminopropanols useful as chemical intermediates for protease-inhibitors | PHARM-ECO LABORATORIES, INCORPORATED (US) | 1997-05-20 | — | — | US | disclosed |
| EP-0769003-A1 | AMINO ACID-DERIVED DIAMINOPROPANOLS | Pharmeco Laboratories, Inc. (US) | 1997-04-23 | — | — | EP | disclosed |
| US-5618966-A | Method forming protease inhibitor synthetic intermediates | PHARM-ECO LABORATORIES, INCORPORATED (US) | 1997-04-08 | — | — | US | disclosed |
| US-5599994-A | Amino acid-derived diaminopropanols | PHARM-ECO LABORATORIES, INC. (US) | 1997-02-04 | — | — | US | disclosed |
| US-5545640-A | VIRICIDES, HIV; AIDS | BIO-MEGA/BOEHRINGER INGELEHEIM RESEARCH INC. (CA) | 1996-08-13 | — | — | US | disclosed |
| WO-1996001788-A2 | AMINO ACID-DERIVED DIAMINOPROPANOLS | PHARM-ECO LABORATORIES, INCORPORATED (US) | 1996-01-25 | — | — | WO | disclosed |
| US-5475138-A | Method preparing amino acid-derived diaminopropanols | PHARM-ECO LABORATORIES INCORPORATED (US) | 1995-12-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040267022-A1 | Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors | DNPEP, PRSS1, TMPRSS15 | EPHX1 1047/4885CSNK1E 2477/4885ANPEP 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.