Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | USP2 | O75604 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.33 |
| ▸ | PLK1 | P53350 | 2/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 2/20 | 0.33 |
| ▸ | PLK2 | Q9NYY3 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6586392 | 0.92 | POLB (0.40) | POLBPKMSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6585853 | 0.91 | POLB (0.37) | POLBPKMSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7981826 | 0.88 | MAPK14 (0.35) | POLBPKMSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6585624 | 0.81 | POLB (0.41) | POLBPKMSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6585811 | 0.81 | POLB (0.37) | POLBPKMALDH1A1KDM4EKMT2A | |
| SCHEMBL6585984 | 0.80 | KMT2A (0.42) | KDM4EMEN1HPGDKMT2AMAPK14 | |
| SCHEMBL6585985 | 0.78 | PDE5A (0.39) | SMN1; SMN2KMT2ATP53THRBGRIN1 | |
| SCHEMBL6586738 | 0.73 | ALDH1A1 (0.43) | POLBSMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL6583611 | 0.72 | KDM4E (0.60) | POLBSMN1; SMN2ALDH1A1KDM4EUSP2 | |
| SCHEMBL6587633 | 0.71 | MAPT (0.39) | POLBALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6265421-B1 | DILATATION OF ARTERIES | ORION CORPORATION (FI) | 2001-07-24 | — | — | US | claimed |
| US-6774103-B1 | Compounds for deactivating phospholamban function on Ca-ATPase (phospholamban inhibitors) | ORION CORPORATION (FI) | 2004-08-10 | — | — | US | disclosed |