Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6846585 | 0.92 | PTGS2 (0.44) | PTGS2PTGS1SOS1NR3C1PGR | |
| SCHEMBL5377415 | 0.88 | PTGS2 (0.40) | PTGS2PTGS1BRD4NR3C1PGR | |
| SCHEMBL6838945 | 0.87 | PTGS2 (0.39) | PTGS2PTGS1ALDH1A1MAPTSCN9A | |
| SCHEMBL6844095 | 0.84 | MEN1 (0.39) | PTGS2PTGS1BRD4PGRKMT2A | |
| SCHEMBL7612387 | 0.84 | PTGS2 (0.39) | PTGS2NR3C1PGRNR3C2KMT2A | |
| SCHEMBL7617482 | 0.79 | PTGS1 (0.44) | PTGS2PTGS1NR3C1PGRNR3C2 | |
| SCHEMBL6704623 | 0.77 | PTGS2 (0.39) | PTGS2PTGS1SOS1BRD4TDP1 | |
| SCHEMBL6846588 | 0.77 | PTGS2 (0.39) | PTGS2PTGS1BRD4CYP1A2MAPT | |
| SCHEMBL6742552 | 0.71 | PTGS2 (0.43) | PTGS2PTGS1NR3C1PGRNR3C2 | |
| SCHEMBL10948590 | 0.70 | HSP90AA1 (0.49) | PTGS2HTR2ASLC6A4KCNH2SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040242637-A1 | Tyrosine kinase inhibitors | HARTMAN GEORGE D (US) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242637-A1 | Tyrosine kinase inhibitors | ERBB2, TYRO3, TIE1 | PTGS2 983/4885PTGS1 791/4885HTR2A 4098/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.