Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 14/20 | 0.39 |
| ▸ | HRH1 | P35367 | 14/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6987654 | 0.92 | HRH2 (0.41) | HRH2HRH1HRH3 | |
| SCHEMBL6983301 | 0.91 | HRH2 (0.42) | HRH2HRH1HRH3 | |
| SCHEMBL6847471 | 0.89 | HRH3 (0.42) | HRH2HRH1HRH3 | |
| SCHEMBL6985870 | 0.89 | HRH2 (0.47) | HRH2HRH1HRH3 | |
| SCHEMBL6987544 | 0.88 | HRH2 (0.43) | HRH2HRH1HRH3KCNH2 | |
| SCHEMBL6842485 | 0.86 | HRH2 (0.45) | HRH2HRH1HRH3KCNH2 | |
| SCHEMBL6847507 | 0.85 | HRH2 (0.50) | HRH2HRH1HRH3 | |
| SCHEMBL6987337 | 0.84 | HRH2 (0.45) | HRH2HRH1HRH3 | |
| SCHEMBL6847679 | 0.84 | GPR119 (0.48) | HRH2HRH1HRH3 | |
| SCHEMBL6981316 | 0.84 | HRH2 (0.44) | HRH2HRH1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1301480-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-04-16 | — | — | EP | claimed |
| WO-2002006223-A1 | 1,3-DISUBSTITUTED AND 1,3,3-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2002-01-24 | — | — | WO | claimed |
| EP-1467727-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | Abbott Laboratories (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059341-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-07-24 | — | — | WO | disclosed |