Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESPL1 | Q14674 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL695579 | 0.86 | POLB (0.42) | ESPL1MAPTTSHRLMNAALDH1A1 | |
| SCHEMBL11844176 | 0.75 | TSHR (0.40) | ESPL1KDM4EMAPTTSHRLMNA | |
| SCHEMBL3213413 | 0.75 | MAPT (0.49) | ESPL1MAPTTSHRLMNAALDH1A1 | |
| SCHEMBL29187025 | 0.74 | TDP1 (0.45) | MAPTLMNAALDH1A1TDP1POLB | |
| SCHEMBL345760 | 0.73 | HSD17B10 (0.48) | MAPTTSHRLMNAALDH1A1TDP1 | |
| SCHEMBL31536932 | 0.73 | HSD17B10 (0.48) | MAPTTSHRLMNAALDH1A1TDP1 | |
| SCHEMBL351824 | 0.73 | TSHR (0.48) | MAPTTSHRLMNAALDH1A1TDP1 | |
| SCHEMBL30945319 | 0.73 | TSHR (0.48) | MAPTTSHRLMNAALDH1A1TDP1 | |
| SCHEMBL2227750 | 0.72 | TSHR (0.48) | MAPTTSHRLMNAALDH1A1TDP1 | |
| SCHEMBL11611414 | 0.72 | POLB (0.46) | ESPL1KDM4EMAPTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986560-B1 | PYRROLO 2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | KAROBIO AB (SE) | 2004-03-24 | — | — | EP | disclosed |
| US-6080754-A | Pyrrolo[2,1,5-cd]indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes | NOVO NORDISK A/S (DK) | 2000-06-27 | — | — | US | disclosed |
| US-6075036-A | Pyrrolo [2,1,5-cd] indolizine derivatives useful in the prevention or treatment of estrogen related diseases or syndromes | NOVO NORDISK (DK) | 2000-06-13 | — | — | US | disclosed |
| EP-0988303-A1 | PYRROLO 2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 2000-03-29 | — | — | EP | disclosed |
| EP-0986560-A1 | PYRROLO 2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 2000-03-22 | — | — | EP | disclosed |
| WO-1998055483-A9 | PYRROLO[2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK AS (DK) | 2000-02-03 | — | — | WO | disclosed |
| WO-1998055483-A1 | PYRROLO[2,1,5-cd]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-12-10 | — | — | WO | disclosed |
| WO-1998055482-A1 | PYRROLO[2,1,5-CD]INDOLIZINE DERIVATIVES USEFUL IN THE PREVENTION OR TREATMENT OF ESTROGEN RELATED DISEASES OR SYNDROMES | NOVO NORDISK A/S (DK) | 1998-12-10 | — | — | WO | disclosed |