Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAK | O14976 | 1/20 | 0.40 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | STK16 | O75716 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.40 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.40 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PTGFR | P43088 | 9/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6841569 | 0.82 | TOP2A (0.42) | GAKEPHB6RIPK2STK16ABL1 | |
| SCHEMBL6414247 | 0.74 | MAPT (0.37) | KMT2AHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL6407586 | 0.72 | MAPT (0.40) | KMT2AHTTSMN1; SMN2CYP3A4THRB | |
| SCHEMBL358762 | 0.71 | GAK (0.61) | GAKEPHB6RIPK2STK16ABL1 | |
| SCHEMBL6845601 | 0.71 | TP53 (0.49) | — | |
| SCHEMBL6847122 | 0.70 | CDC25B (0.44) | ABL1KMT2AHTTTHRB | |
| SCHEMBL6410278 | 0.70 | MAPT (0.36) | KMT2AHTTSMN1; SMN2CYP3A4 | |
| SCHEMBL7638107 | 0.68 | TOP2A (0.60) | KMT2AHTTSMN1; SMN2L3MBTL1CYP3A4 | |
| SCHEMBL6414212 | 0.68 | MAPT (0.39) | KMT2AHTTSMN1; SMN2CYP3A4THRB | |
| SCHEMBL6407055 | 0.67 | HPGD (0.40) | KMT2AHTTSMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1202992-B1 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | CEPHALON FRANCE (FR) | 2004-09-15 | — | — | EP | disclosed |
| EP-1202992-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001012631-A2 | ASCIDIDEMIN DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS | LABORATOIRE L. LAFON (FR) | 2001-02-22 | — | — | WO | disclosed |