SCHEMBL6407586

SCHEMBL6407586

COc1ccnc2c1C(=O)c1nccc(C)c1C2=O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.40
MAPK1 P28482 4/20 0.40
HTT P42858 4/20 0.40
KMT2A Q03164 4/20 0.40
KDM4E B2RXH2 4/20 0.40
LMNA P02545 3/20 0.40
HPGD P15428 2/20 0.40
TDP1 Q9NUW8 2/20 0.40
POLB P06746 2/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
CYP3A4 P08684 1/20 0.40
CYP2D6 P10635 1/20 0.40
CYP2C9 P11712 1/20 0.40
CASP1 P29466 1/20 0.40
CYP2C19 P33261 1/20 0.40
CREBBP Q92793 1/20 0.40
ATM Q13315 1/20 0.40
HKDC1 Q2TB90 1/20 0.40
USP8 P40818 1/20 0.40
USP7 Q93009 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6414212 0.95 MAPT (0.39) MAPTMAPK1HTTKMT2AKDM4E
SCHEMBL6597622 0.85 NOS2 (0.43) KMT2AKDM4ETDP1USP8ALDH1A1
SCHEMBL6407055 0.84 HPGD (0.40) MAPTMAPK1HTTKMT2AKDM4E
SCHEMBL6414247 0.82 MAPT (0.37) MAPTMAPK1HTTKMT2AKDM4E
SCHEMBL6415751 0.79 HPGD (0.39) MAPTMAPK1HTTKMT2AKDM4E
SCHEMBL6410278 0.78 MAPT (0.36) MAPTMAPK1HTTKMT2AKDM4E
SCHEMBL7991158 0.77 NOS2 (0.43) KMT2AKDM4ETDP1ALDH1A1MEN1
SCHEMBL6407178 0.77 MAPT (0.50) MAPTMAPK1HTTKMT2AKDM4E
SCHEMBL6413377 0.75 NSD2 (0.40) MAPTMAPK1HTTKMT2AKDM4E
SCHEMBL6597630 0.75 CES1 (0.36) KMT2ATDP1USP8MEN1S100A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1202993-B1 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LAFON LABOR (FR) 2005-10-19 EP disclosed
US-6809096-B1 SUCH AS 11-METHOXY-7H-PYRIDO(4,3,2-DE)(1,7)PHENANTHROLINE-7-ONE; ANTITUMOR AGENTS LABORATOIRE L. LAFON (FR) 2004-10-26 US disclosed
EP-1202993-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2002-05-08 EP disclosed
WO-2001012632-A2 PHENANTHROLINE-7-ONE DERIVATIVES AND THEIR THERAPEUTIC USES LABORATOIRE L. LAFON (FR) 2001-02-22 WO disclosed