Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 15/20 | 0.44 |
| ▸ | HRH1 | P35367 | 15/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6847435 | 0.90 | HRH2 (0.47) | HRH2HRH1MAOBHRH3 | |
| SCHEMBL5218123 | 0.89 | HRH2 (0.48) | HRH2HRH1MAOBHRH3 | |
| SCHEMBL6847505 | 0.87 | HRH2 (0.48) | HRH2HRH1MAOBHRH3 | |
| SCHEMBL6848832 | 0.85 | HRH2 (0.59) | HRH2HRH1MAOBHRH3 | |
| SCHEMBL6847234 | 0.84 | ALDH1A1 (0.47) | HRH2HRH1ALDH1A1KMT2AMEN1 | |
| SCHEMBL6848186 | 0.84 | ALDH1A1 (0.39) | ALDH1A1KMT2AHRH3 | |
| SCHEMBL6847912 | 0.84 | HRH2 (0.51) | HRH2HRH1MAOBHRH3 | |
| SCHEMBL6848752 | 0.84 | HRH2 (0.61) | HRH2HRH1MAOBHRH3 | |
| SCHEMBL6846776 | 0.83 | HCRTR1 (0.46) | HRH2HRH1ALDH1A1HRH3 | |
| SCHEMBL6847370 | 0.83 | HRH2 (0.59) | HRH2HRH1MAOBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1467727-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | Abbott Laboratories (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003059341-A1 | 1,3-DISUBSTITUTED AND 1,3,3,-TRISUBSTITUTED PYRROLIDINES AS HISTAMINE-3 RECEPTOR LIGANDS AND THEIR THERAPEUTIC APPLICATIONS | ABBOTT LABORATORIES (US) | 2003-07-24 | — | — | WO | disclosed |