Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.67 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.67 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.67 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.67 |
| ▸ | PRKX | P51817 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | MYLK | Q15746 | 3/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | GMNN | O75496 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039708 | 0.86 | ROCK2 (0.71) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL7049151 | 0.84 | ROCK2 (0.71) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL13513878 | 0.83 | ROCK2 (0.77) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Hydroxyfasudil SCHEMBL29473349 | 0.80 | ROCK2 (0.75) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Hydroxyfasudil SCHEMBL30309462 | 0.80 | ROCK2 (0.75) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Hydroxyfasudil SCHEMBL1827528 | 0.80 | ROCK2 (0.75) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL2908958 | 0.80 | ROCK2 (0.75) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL6845278 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| SCHEMBL7047822 | 0.80 | ROCK2 (0.68) | ROCK2ROCK1PRKCEPRKCDPRKD1 | |
| Hydroxyfasudil SCHEMBL30198128 | 0.79 | ROCK2 (0.73) | ROCK2ROCK1PRKCEPRKCDPRKD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7867999-B1 | Hydroxyamino- and amino-substituted pyridine analogs for treating rho kinase-mediated diseases and conditions | ALCON RESEARCH, LTD. (US) | 2011-01-11 | — | — | US | disclosed |