Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5811772 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2CYP2D6ATMKDM4ELMNA | |
| SCHEMBL6854044 | 0.78 | SMN1; SMN2 (0.52) | SMN1; SMN2ATMKDM4ELMNANPC1 | |
| SCHEMBL23704415 | 0.78 | SMN1; SMN2 (0.55) | SMN1; SMN2ATMKDM4ELMNANPC1 | |
| SCHEMBL31337216 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2ATMKDM4ELMNANPC1 | |
| SCHEMBL20777186 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2ATMKDM4ELMNAHDAC6 | |
| SCHEMBL6852080 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2ATMKDM4ELMNAHDAC6 | |
| SCHEMBL1997873 | 0.74 | PSMB8 (0.56) | SMN1; SMN2ATMKDM4ELMNANPC1 | |
| SCHEMBL20448743 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2ATMKDM4ELMNAHDAC6 | |
| SCHEMBL484207 | 0.72 | NPC1 (0.55) | SMN1; SMN2ATMKDM4ELMNANPC1 | |
| SCHEMBL104281 | 0.70 | HDAC6 (0.61) | SMN1; SMN2CYP2D6KDM4ELMNAHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825170-B2 | ERYTHROMYCIN TYPE MACROLIDE WITH A FUSED OXAZOLONE RING | ORTHO-MCNEIL PHARMACEUTICAL, INC. | 2004-11-30 | — | — | US | disclosed |
| EP-1453847-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | Ortho-Mcneil Pharmaceutical, Inc. (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003050132-A1 | 6-O-ACYL KETOLIDE DERIVATIVES OF ERYTHROMYCINE USEFUL AS ANTIBACTERIALS | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2003-06-19 | — | — | WO | disclosed |