SCHEMBL6849366

SCHEMBL6849366

O=C(O)CCC(CO)NCc1cccc2cc[nH]c12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KEAP1 Q14145 1/20 0.40
BACE1 P56817 1/20 0.39
ADORA2A P29274 1/20 0.39
ADORA1 P30542 1/20 0.39
MAPK1 P28482 1/20 0.37
MAPK8 P45983 1/20 0.37
MAPK9 P45984 1/20 0.37
MAPK10 P53779 1/20 0.37
HDAC1 Q13547 3/20 0.37
HDAC2 Q92769 3/20 0.37
HDAC3 O15379 2/20 0.37
HDAC4 P56524 2/20 0.37
HDAC7 Q8WUI4 2/20 0.37
HDAC10 Q969S8 2/20 0.37
HDAC11 Q96DB2 2/20 0.37
HDAC8 Q9BY41 2/20 0.37
HDAC6 Q9UBN7 2/20 0.37
HDAC9 Q9UKV0 2/20 0.37
HDAC5 Q9UQL6 2/20 0.37
PDPK1 O15530 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6334183 0.83 MAPK1 (0.38) KEAP1BACE1ADORA2AADORA1MAPK1
SCHEMBL31370047 0.76 KEAP1 (0.49) KEAP1BACE1ADORA2AADORA1MAPK8
SCHEMBL2262619 0.75 MAPK1 (0.46) KEAP1BACE1ADORA2AADORA1MAPK1
SCHEMBL6328785 0.75 HTR2A (0.38) KEAP1BACE1ADORA2AADORA1MAPK1
SCHEMBL7476355 0.71 KEAP1 (0.56) KEAP1BACE1ADORA2AADORA1MAPK8
SCHEMBL29564932 0.71 KEAP1 (0.56) KEAP1BACE1ADORA2AADORA1MAPK8
SCHEMBL31369960 0.69 KEAP1 (0.46) KEAP1BACE1ADORA2AADORA1MAPK8
SCHEMBL1395817 0.67 HTR2A (0.52) KEAP1BACE1ADORA2AADORA1MAPK1
SCHEMBL29869958 0.67 AHR (0.50) KEAP1BACE1ADORA2AADORA1MAPK8
SCHEMBL1137818 0.67 AHR (0.50) KEAP1BACE1ADORA2AADORA1MAPK8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1250334-B1 Medicaments useful for the treatment of proliferative diseases LILLY CO ELI (US) 2004-05-19 EP disclosed