Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 4/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6418240 | 0.86 | GRM6 (0.40) | ADORA1TAAR1MEN1ALDH1A1MAPT | |
| SCHEMBL6432093 | 0.79 | PTPN2 (0.34) | ALDH1A1MAPTPOLBKCNH2 | |
| SCHEMBL6413368 | 0.74 | CXCR2 (0.41) | ALDH1A1MAPTLMNA | |
| SCHEMBL6413287 | 0.67 | ALDH1A1 (0.41) | ADORA1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL6414792 | 0.66 | SLC18A2 (0.43) | — | |
| SCHEMBL6415638 | 0.63 | PTPN1 (0.45) | — | |
| SCHEMBL1787090 | 0.60 | ADORA1 (1.00) | ADORA1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL29116214 | 0.59 | ADORA1 (0.43) | ADORA1MEN1ALDH1A1MAPTKMT2A | |
| SCHEMBL28328103 | 0.59 | ABCB1 (0.60) | ALDH1A1KCNH2 | |
| SCHEMBL23827466 | 0.58 | ALDH1A1 (0.61) | ADORA1TAAR1MEN1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1404682-A1 | METHOD OF INHIBITING PTP 1B AND/OR T-CELL PTP AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | Novo Nordisk A/S (DK) | 2004-04-07 | — | — | EP | disclosed |
| WO-2003002569-A1 | METHOD OF INHIBITING PTP 1B AND/OR T-CELL PTP AND/OR OTHER PTPASES WITH AN ASP RESIDUE AT POSITION 48 | NOVO NORDISK A/S (DK) | 2003-01-09 | — | — | WO | disclosed |