Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259210 | 0.82 | MAPT (0.46) | NPC1RAB9ARAF1BRAFALDH1A1 | |
| SCHEMBL13891521 | 0.78 | ELANE (0.47) | NPC1RAB9ARAF1BRAFKDR | |
| SCHEMBL3452438 | 0.72 | C1R (0.55) | NPC1RAB9ARAF1BRAFALDH1A1 | |
| SCHEMBL3452122 | 0.71 | C1R (0.63) | NPC1RAB9ARAF1BRAFALDH1A1 | |
| SCHEMBL4268146 | 0.71 | ELANE (0.47) | NPC1RAB9ARAF1BRAFKDR | |
| SCHEMBL4259446 | 0.71 | C1R (0.46) | NPC1RAB9ARAF1BRAFALDH1A1 | |
| SCHEMBL4263278 | 0.70 | ELANE (0.46) | NPC1RAB9ARAF1BRAFKDR | |
| SCHEMBL4258175 | 0.70 | ELANE (0.46) | NPC1RAB9ARAF1BRAFKDR | |
| SCHEMBL3453188 | 0.70 | ELANE (0.76) | NPC1RAB9AKDRTEKALDH1A1 | |
| SCHEMBL4258656 | 0.70 | ELANE (0.43) | NPC1RAB9ARAF1BRAFKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446125-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | Alizyme Therapeutics Limited (GB) | 2004-08-18 | — | — | EP | claimed |
| WO-2003020282-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LIMITED (GB) | 2003-03-13 | — | — | WO | claimed |