Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | C1R | P00736 | 6/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PLAU | P00749 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4263283 | 0.87 | C1R (0.46) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL13891444 | 0.82 | ELANE (0.44) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4260491 | 0.82 | ELANE (0.52) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL3453188 | 0.78 | ELANE (0.76) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4261224 | 0.78 | ELANE (0.56) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4259315 | 0.78 | ELANE (0.51) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4259210 | 0.77 | MAPT (0.46) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL3452438 | 0.77 | C1R (0.55) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL3452122 | 0.76 | C1R (0.63) | ELANENPC1RAB9AALDH1A1KDM4E | |
| SCHEMBL4268146 | 0.74 | ELANE (0.47) | ELANENPC1RAB9AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446125-B1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LTD (GB) | 2009-04-29 | — | — | EP | claimed |
| US-20090029978-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LIMITED (GB) | 2009-01-29 | — | — | US | claimed |
| US-7407954-B2 | Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity | ALIZYME THERAPEUTICS LIMITED (GB) | 2008-08-05 | — | — | US | claimed |
| US-20050075336-A1 | Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity | NORGINE B.V. (NL) | 2005-04-07 | — | — | US | claimed |
| EP-1446125-B1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LTD (GB) | 2009-04-29 | — | — | EP | disclosed |
| EP-1446125-B1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LTD (GB) | 2009-04-29 | — | — | EP | disclosed |
| US-20090029978-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LIMITED (GB) | 2009-01-29 | — | — | US | disclosed |
| US-20090029978-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LIMITED (GB) | 2009-01-29 | — | — | US | disclosed |
| US-20090029978-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | ALIZYME THERAPEUTICS LIMITED (GB) | 2009-01-29 | — | — | US | disclosed |
| US-7407954-B2 | Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity | ALIZYME THERAPEUTICS LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| US-7407954-B2 | Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity | ALIZYME THERAPEUTICS LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| US-7407954-B2 | Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity | ALIZYME THERAPEUTICS LIMITED (GB) | 2008-08-05 | — | — | US | disclosed |
| US-20050075336-A1 | Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity | NORGINE B.V. (NL) | 2005-04-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050075336-A1 | Thieno-(1,3)-oxazin-4-ones with lipase inhibiting activity | LPL, LIPE, LIPC | ELANE 282/4885NPC1 725/4885RAB9A 4095/4885 |
| US-20090029978-A1 | THIENO-(1,3)-OXAZIN-4-ONES WITH LIPASE INHIBITING ACTIVITY | LPL, LIPE, LIPC | ELANE 282/4885NPC1 725/4885RAB9A 4095/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.